Abuse Potential Evaluation with Pharmaco-MRI
A means of assessing abuse liability of experimental drugs in man using MRI methods and evaluating and mitigating abuse risk of novel Mechanisms-of-Action.
Assessment of abuse potential of experimental drugs that engage with novel Mechanisms of Action is required as part of their development. The FDA strongly encourages industry to pay more attention to the risk for drug abuse in experimental drugs to avoid future non-medical use.
Today, a variety of preclinical animal models for drug dependence and abuse exist albeit with varying translational properties. Because of this, innovative drug development faces a significant risk of choosing a suboptimal animal model, dosing and administration regime.
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