HepaRG-CAR: a new human liver cell line
HepaRG cells outperform all other proliferative sources of human hepatocytes in liver functions. Now we
modified the HepaRG cell line by stable lentiviral overexpression of the constitutive androstane receptor
(CAR), a regulator of e.g. detoxification and energy metabolism, which has the following advantages:
- High liver functionality & increased mitochondrial energy metabolism in monolayer, particularly in 1.7%
dimethylsulfoxide (DMSO) - Low costs: expandable in culture medium with only 2.5% fetal bovine serum
- Highly resistant to 1.7% DMSO toxicity, used for hepatic differentiation
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